Human B-1 and B-2 B Cells Develop from Lin-CD34+CD38lo Stem Cells.

ABSTRACT: The B-1 B cell population is an important bridge between innate and adaptive immunity primarily because B-1 cells produce natural Ab. Murine B-1 and B-2 cells arise from distinct progenitors; however, in humans, in part because it has been difficult to discriminate between them phenotypically, efforts to pinpoint the developmental origins of human B-1 and B-2 cells have lagged. To characterize progenitors of human B-1 and B-2 cells, we separated cord blood and bone marrow Lin^-CD34⁺ hematopoietic stem cells into Lin^-CD34⁺CD38^lo and Lin^-CD34⁺CD38^hi populations. We found that transplanted Lin^-CD34⁺CD38^lo cells, but not Lin^-CD34⁺CD38^hi cells,

SUBMITTER: Quach TD 

PROVIDER: S-EPMC5363078 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature