Immunological consequences of strain variation within the Mycobacterium tuberculosis complex.

ABSTRACT: In 2015, there were an estimated 10.4 million new cases of tuberculosis (TB) globally, making it one of the leading causes of death due to an infectious disease. TB is caused by members of the Mycobacterium tuberculosis complex (MTBC), with human disease resulting from infection by M. tuberculosis sensu stricto and M. africanum. Recent progress in genotyping techniques, in particular the increasing availability of whole genome sequence data, has revealed previously under appreciated levels of genetic diversity within the MTBC. Several studies have shown that this genetic diversity may translate into differences in TB transmission, clinical manifestations of disease, and host immune responses. This suggests the existence of MTBC genotype-dependent host-pathogen interactions which may influe

SUBMITTER: Tientcheu LD 

PROVIDER: S-EPMC5363233 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature