Bringing Neural Cell Therapies to the Clinic: Past and Future Strategies.

ABSTRACT: Cell replacement therapy in the nervous system has a rich history, with ∼40 years of research and ∼30 years of clinical experience. There is compelling evidence that appropriate cells can integrate and function in the dysfunctioning human nervous system, but the clinical results are mixed in practice. A number of factors conspire to vary patient outcome: the indication, cell source, patient selection, and team performing transplantation are all variables that can affect efficacy. Most early clinical trials have used fetal cells, a limited cell source that resists scale and standardization. Direct fetal cell transplantation creates significant challenges to commercialization that is the ultimate goal of an effective cell therapy. One approach to help scale and standardize fetal cell prepara

SUBMITTER: Irion S 

PROVIDER: S-EPMC5363320 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature