A sweet taste receptor-dependent mechanism of glucosensing in hypothalamic tanycytes.

ABSTRACT: Hypothalamic tanycytes are glial-like glucosensitive cells that contact the cerebrospinal fluid of the third ventricle, and send processes into the hypothalamic nuclei that control food intake and body weight. The mechanism of tanycyte glucosensing remains undetermined. While tanycytes express the components associated with the glucosensing of the pancreatic β cell, they respond to nonmetabolisable glucose analogues via an ATP receptor-dependent mechanism. Here, we show that tanycytes in rodents respond to non-nutritive sweeteners known to be ligands of the sweet taste (Tas1r2/Tas1r3) receptor. The initial sweet tastant-evoked response, which requires the presence of extracellular Ca²⁺ , leads to release of ATP and a larger propagating Ca²⁺ response mediated by P2Y1 r

SUBMITTER: Benford H 

PROVIDER: S-EPMC5363357 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature