Neuropsychological outcomes from constant current deep brain stimulation for Parkinson's disease.

ABSTRACT:

Objective

The aim of this study was to evaluate the neurobehavioral safety of constant-current subthalamic deep brain stimulation and to compare the neuropsychological effects of stimulation versus electrode placement alone.

Methods

A total of 136 patients with Parkinson's disease underwent bilateral subthalamic device implantation in this randomized trial. Patients received stimulation either immediately after device implantation (n = 101; active stimulation) or beginning 3 months after surgery (n = 35; delayed activation control). Patients were administered neuropsychological tests before, 3, and 12 months after device implantation.

Results

Neuropsychological change in stimulation and control groups were comparable. Within-group analyses revealed declines in categor

SUBMITTER: Troster AI 

PROVIDER: S-EPMC5363377 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature