Depiction of microglial activation in aging and dementia: Positron emission tomography with [¹¹C]DPA713 versus [¹¹C]( R)PK11195.

ABSTRACT: The presence of activated microglia in the brains of healthy elderly people is a matter of debate. We aimed to clarify the degree of microglial activation in aging and dementia as revealed by different tracers by comparing the binding potential (BP_ND) in various brain regions using a first-generation translocator protein (TSPO) tracer [¹¹C]( R)PK11195 and a second-generation tracer [¹¹C]DPA713. The BP_ND levels, estimated using simplified reference tissue models, were compared among healthy young and elderly individuals and patients with Alzheimer's disease (AD) and were correlated with clinical scores. An analysis of variance showed category-dependent elevation in levels of [¹¹C]DPA713 BP_ND in all brain regions and showed a

SUBMITTER: Yokokura M 

PROVIDER: S-EPMC5363467 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature