Relevance of Fusion Genes in Pediatric Cancers: Toward Precision Medicine.

ABSTRACT: Pediatric cancers differ from adult tumors, especially by their very low mutational rate. Therefore, their etiology could be explained in part by other oncogenic mechanisms such as chromosomal rearrangements, supporting the possible implication of fusion genes in the development of pediatric cancers. Fusion genes result from chromosomal rearrangements leading to the juxtaposition of two genes. Consequently, an abnormal activation of one or both genes is observed. The detection of fusion genes has generated great interest in basic cancer research and in the clinical setting, since these genes can lead to better comprehension of the biological mechanisms of tumorigenesis and they can also be used as therapeutic targets and diagnostic or prognostic biomarkers. In this review, we discuss the m

SUBMITTER: Dupain C 

PROVIDER: S-EPMC5363511 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature