Environmental enrichment enhances synaptic plasticity by internalization of striatal dopamine transporters.

ABSTRACT: Environmental enrichment (EE) with a complex combination of physical, cognitive and social stimulations enhances synaptic plasticity and behavioral function. However, the mechanism remains to be elucidated in detail. We aimed to investigate dopamine-related synaptic plasticity underlying functional improvement after EE. For this, six-week-old CD-1 mice were randomly allocated to EE or standard conditions for two months. EE significantly enhanced behavioral functions such as rotarod and ladder walking tests. In a [¹⁸F]FPCIT positron emission tomography scan, binding values of striatal DAT were significantly decreased approximately 18% in the EE mice relative to the control mice. DAT inhibitor administrated to establish the relationship of the DAT down-regulation to the treatment

SUBMITTER: Kim MS 

PROVIDER: S-EPMC5363660 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature