Hypoxic preconditioning enhances neural stem cell transplantation therapy after intracerebral hemorrhage in mice.

ABSTRACT: Previous studies have shown that intraparenchymal transplantation of neural stem cells ameliorates neurological deficits in animals with intracerebral hemorrhage. However, hemoglobin in the host brain environment causes massive grafted cell death and reduces the effectiveness of this approach. Several studies have shown that preconditioning induced by sublethal hypoxia can markedly improve the tolerance of treated subjects to more severe insults. Therefore, we investigated whether hypoxic preconditioning enhances neural stem cell resilience to the hemorrhagic stroke environment and improves therapeutic effects in mice. To assess whether hypoxic preconditioning enhances neural stem cell survival when exposed to hemoglobin, neural stem cells were exposed to 5% hypoxia for 24 hours before exp

SUBMITTER: Wakai T 

PROVIDER: S-EPMC5363661 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature