Featured Article: Chemotherapeutic delivery using pH-responsive, affinity-based release.

ABSTRACT: Doxorubicin is a chemotherapeutic drug typically administered systemically which frequently leads to cardiac and hepatic toxicities. Local delivery to a tumor has a chance to mitigate some of these toxicities and can further be mitigated by including a means of tumor-specific drug release. Our laboratory has explored the use of molecular interactions to control the rate of drug release beyond that capable of diffusion alone. To this system, we added an additional affinity group (adamantane) to doxorubicin through a pH-sensitive hydrazone bond. The result was a modified doxorubicin which had an even higher affinity to our drug delivery polymer, and virtually no release in normal conditions, but showed accelerated release of drug in tumor-like low pH. Further, we show that adamantane-modifie

SUBMITTER: Cyphert EL 

PROVIDER: S-EPMC5363690 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature