Rho kinase activity governs arteriolar myogenic depolarization.

ABSTRACT: Cerebral arterioles contribute critically to regulation of local and global blood flow within the brain. Dysfunction of these blood vessels is implicated in numerous cardiovascular diseases. However, treatments are limited due to incomplete understanding of fundamental control mechanisms at this level of circulation. Emerging evidence points to a key role of Rho-associated protein kinase in regulation of microvascular contractility. This study sought to decipher the mechanisms of Rho-associated protein kinase-mediated myogenic vasoconstriction in cerebral parenchymal arterioles. Here, we report that the Rho-associated protein kinase inhibitor H1152 strongly attenuated pressure-induced constriction, cytosolic [Ca²⁺] increases, and depolarization of isolated parenchymal arterioles

SUBMITTER: Li Y 

PROVIDER: S-EPMC5363734 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature