Cerebroprotection by the neuronal PGE2 receptor EP2 after intracerebral hemorrhage in middle-aged mice.

ABSTRACT: Inflammatory responses mediated by prostaglandins such as PGE₂ may contribute to secondary brain injury after intracerebral hemorrhage (ICH). However, the cell-specific signaling by PGE₂ receptor EP2 differs depending on whether the neuropathic insult is acute or chronic. Using genetic and pharmacologic approaches, we investigated the role of EP2 receptor in two mouse models of ICH induced by intrastriatal injection of collagenase or autologous arterial whole blood. We used middle-aged male mice to enhance the clinical relevance of the study. EP2 receptor was expressed in neurons but not in astrocytes or microglia after collagenase-induced ICH. Brain injury after collagenase-induced ICH was associated with enhanced cellular and molecular inflammatory responses, oxidat

SUBMITTER: Wu H 

PROVIDER: S-EPMC5363749 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature