White matter hyperintensity microstructure in amyloid dysmetabolism.

ABSTRACT: Accumulating evidence suggests associations between cerebrovascular disease (CVD) and Alzheimer's disease (AD). White matter hyperintensities of presumed vascular origin (WMHs) are increased in subjects with mild cognitive impairment (MCI) and AD, but the exact pathomechanistic link is unknown. The current study investigated effects of amyloid dysmetabolism on the microstructure of WMHs in subjects with MCI or subjective cognitive decline (N = 51), dichotomized according to pathological or normal levels of amyloid-β peptide (Aβ₄₂) in cerebrospinal fluid (CSF). Thirty-one subjects with low CSF Aβ₄₂ (Aβ+) and 20 subjects with normal CSF Aβ₄₂ (Aβ-) were assessed with magnetic resonance diffusion tensor imaging (DTI), and fractional anisotropy (FA), radial diff

SUBMITTER: Kalheim LF 

PROVIDER: S-EPMC5363752 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature