Age-associated physiological and pathological changes at the blood-brain barrier: A review.

ABSTRACT: The age-associated decline of the neurological and cognitive functions becomes more and more serious challenge for the developed countries with the increasing number of aged populations. The morphological and biochemical changes in the aging brain are the subjects of many extended research projects worldwide for a long time. However, the crucial role of the blood-brain barrier (BBB) impairment and disruption in the pathological processes in age-associated neurodegenerative disorders received special attention just for a few years. This article gives an overview on the major elements of the blood-brain barrier and its supporting mechanisms and also on their alterations during development, physiological aging process and age-associated neurodegenerative disorders (Alzheimer's disease, multip

SUBMITTER: Erdo F 

PROVIDER: S-EPMC5363756 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature