Differential gene expression in patients with subsyndromal symptomatic depression and major depressive disorder.

ABSTRACT:

Background

Subsyndromal symptomatic depression (SSD) is a subtype of subthreshold depressive and can lead to significant psychosocial functional impairment. Although the pathogenesis of major depressive disorder (MDD) and SSD still remains poorly understood, a set of studies have found that many same genetic factors play important roles in the etiology of these two disorders. Nowadays, the differential gene expression between MDD and SSD is still unknown. In our previous study, we compared the expression profile and made the classification with the leukocytes by using whole-genome cRNA microarrays among drug-free first-episode subjects with SSD, MDD and matched healthy controls (8 subjects in each group), and finally determined 48 gene expression signatures. Based on these findings

SUBMITTER: Yang C 

PROVIDER: S-EPMC5363801 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature