A genome-wide association study of thyroid stimulating hormone and free thyroxine in Danish children and adolescents.

ABSTRACT:

Background

Hypothyroidism is associated with obesity, and thyroid hormones are involved in the regulation of body composition, including fat mass. Genome-wide association studies (GWAS) in adults have identified 19 and 6 loci associated with plasma concentrations of thyroid stimulating hormone (TSH) and free thyroxine (fT4), respectively.

Objective

This study aimed to identify and characterize genetic variants associated with circulating TSH and fT4 in Danish children and adolescents and to examine whether these variants associate with obesity.

Methods

Genome-wide association analyses of imputed genotype data with fasting plasma concentrations of TSH and fT4 from a population-based sample of Danish children, adolescents, and young adults, and a group of children, adol

SUBMITTER: Nielsen TR 

PROVIDER: S-EPMC5363901 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature