Low sphingosine-1-phosphate plasma levels are predictive for increased mortality in patients with liver cirrhosis.

ABSTRACT:

Background & aim

The association of circulating sphingosine-1-phosphate (S1P), a bioactive lipid involved in various cellular processes, and related metabolites such as sphinganine-1-phosphate (SA1P) and sphingosine (SPH) with mortality in patients with end-stage liver disease is investigated in the presented study. S1P as a bioactive lipid mediator, is involved in several cellular processes, however, in end-stage liver disease its role is not understood.

Methods

The study cohort consisted of 95 patients with end-stage liver disease and available information on one-year outcome. The median MELD (Model for end-stage liver disease) score was 12.41 (Range 6.43-39.63). The quantification of sphingolipids in citrated plasma specimen was performed after methanolic protein precipit

SUBMITTER: Becker S 

PROVIDER: S-EPMC5363961 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature