Genome-Wide Association Study of the Genetic Determinants of Emphysema Distribution.

ABSTRACT:

Rationale

Emphysema has considerable variability in the severity and distribution of parenchymal destruction throughout the lungs. Upper lobe-predominant emphysema has emerged as an important predictor of response to lung volume reduction surgery. Yet, aside from alpha-1 antitrypsin deficiency, the genetic determinants of emphysema distribution remain largely unknown.

Objectives

To identify the genetic influences of emphysema distribution in non-alpha-1 antitrypsin-deficient smokers.

Methods

A total of 11,532 subjects with complete genotype and computed tomography densitometry data in the COPDGene (Genetic Epidemiology of Chronic Obstructive Pulmonary Disease [COPD]; non-Hispanic white and African American), ECLIPSE (Evaluation of COPD Longitudinally to Identify Predi

SUBMITTER: Boueiz A 

PROVIDER: S-EPMC5363968 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature