Signaling and Transcription Factors during Inner Ear Development: The Generation of Hair Cells and Otic Neurons.

ABSTRACT: Integration between cell signals and bHLH transcription factors plays a prominent role during the development of hair cells of the inner ear. Hair cells are the sensory receptors of the inner ear, responsible for the mechano-transduction of sound waves into electrical signals. They derive from multipotent progenitors that reside in the otic placode. Progenitor commitment is the result of cell signaling from the surrounding tissues that result in the restricted expression of SoxB1 transcription factors, Sox2 and Sox3. In turn, they induce the expression of Neurog1 and Atoh1, two bHLH factors that specify neuronal and hair cell fates, respectively. Neuronal and hair cell development, however, do not occur simultaneously. Hair cell development is prevented during neurogenesis and prosensory s

SUBMITTER: Galvez H 

PROVIDER: S-EPMC5364141 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature