Variability of control data and relevance of observed group differences in five oral toxicity studies with genetically modified maize MON810 in rats.

ABSTRACT: The data of four 90-day feeding trials and a 1-year feeding trial with the genetically modified (GM) maize MON810 in Wistar Han RCC rats performed in the frame of EU-funded project GRACE were analysed. Firstly, the data obtained from the groups having been fed the non-GM maize diets were combined to establish a historical control data set for Wistar Han RCC rats at the animal housing facility (Slovak Medical University, Bratislava, Slovakia). The variability of all parameters is described, and the reference values and ranges have been derived. Secondly, the consistency of statistically significant differences found in the five studies was analysed. In order to do so, the body weight development, organ weight, haematology and clinical biochemistry data were compared between the studies. Bas

SUBMITTER: Schmidt K 

PROVIDER: S-EPMC5364247 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature