Hippocampal morphology and cognitive functions in community-dwelling older people: the Lothian Birth Cohort 1936.

ABSTRACT: Structural measures of the hippocampus have been linked to a variety of memory processes and also to broader cognitive abilities. Gross volumetry has been widely used, yet the hippocampus has a complex formation, comprising distinct subfields which may be differentially sensitive to the deleterious effects of age, and to different aspects of cognitive performance. However, a comprehensive analysis of multidomain cognitive associations with hippocampal deformations among a large group of cognitively normal older adults is currently lacking. In 654 participants of the Lothian Birth Cohort 1936 (mean age = 72.5, SD = 0.71 years), we examined associations between the morphology of the hippocampus and a variety of memory tests (spatial span, letter-number sequencing, verbal recall, and digit ba

SUBMITTER: Valdes Hernandez MDC 

PROVIDER: S-EPMC5364373 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature