Ontology highlight
ABSTRACT:
SUBMITTER: Schweiger M
PROVIDER: S-EPMC5364409 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Nature communications 20170322
Elevated circulating fatty acids (FAs) contribute to the development of obesity-associated metabolic complications such as insulin resistance (IR) and non-alcoholic fatty liver disease (NAFLD). Hence, reducing adipose tissue lipolysis to diminish the mobilization of FAs and lower their respective plasma concentrations represents a potential treatment strategy to counteract obesity-associated disorders. Here we show that specific inhibition of adipose triglyceride lipase (Atgl) with the chemical ...[more]