Ontology highlight
ABSTRACT:
SUBMITTER: Kage F
PROVIDER: S-EPMC5364437 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Kage Frieda F Winterhoff Moritz M Dimchev Vanessa V Mueller Jan J Thalheim Tobias T Freise Anika A Brühmann Stefan S Kollasser Jana J Block Jennifer J Dimchev Georgi G Geyer Matthias M Schnittler Hans-Joachim HJ Brakebusch Cord C Stradal Theresia E B TE Carlier Marie-France MF Sixt Michael M Käs Josef J Faix Jan J Rottner Klemens K
Nature communications 20170322
Migration frequently involves Rac-mediated protrusion of lamellipodia, formed by Arp2/3 complex-dependent branching thought to be crucial for force generation and stability of these networks. The formins FMNL2 and FMNL3 are Cdc42 effectors targeting to the lamellipodium tip and shown here to nucleate and elongate actin filaments with complementary activities in vitro. In migrating B16-F1 melanoma cells, both formins contribute to the velocity of lamellipodium protrusion. Loss of FMNL2/3 function ...[more]