Unknown

Dataset Information

0

The miR-24-3p/p130Cas: a novel axis regulating the migration and invasion of cancer cells.

ABSTRACT: MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression by suppressing translation or facilitating mRNA decay. Differential expression of miRNAs is involved in the pathogenesis of several diseases including cancer. Here, we investigated the role of-miR-24-3p as a downregulated miRNA in metastatic cancer. miR-24-3p was decreased in metastatic cancer and lower expression of miR-24-3p was related to poor survival of cancer patients. Consistently, ectopic expression of miR-24-3p suppressed the cell migration, invasion, and proliferation of MCF7, Hep3B, B16F10, SK-Hep1, and PC-3 cells by directly targeting p130Cas. Stable expression of p130Cas restored miR-24-3p-mediated inhibition of cell migration and invasion. These results suggest that miR-24-3p functions as a tumor suppressor and the miR-24-3p/p130Cas axis is a novel factor of cancer progression by regulating cell migration and invasion.

SUBMITTER: Kang H 

PROVIDER: S-EPMC5364481 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

The miR-24-3p/p130Cas: a novel axis regulating the migration and invasion of cancer cells.

Kang Hoin H   Rho Jun Gi JG   Kim Chongtae C   Tak Hyosun H   Lee Heejin H   Ji Eunbyul E   Ahn Sojin S   Shin A-Ri AR   Cho Hyun-Il HI   Huh Yun Hyun YH   Song Woo Keun WK   Kim Wook W   Lee Eun Kyung EK  

Scientific reports 20170324

MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression by suppressing translation or facilitating mRNA decay. Differential expression of miRNAs is involved in the pathogenesis of several diseases including cancer. Here, we investigated the role of-miR-24-3p as a downregulated miRNA in metastatic cancer. miR-24-3p was decreased in metastatic cancer and lower expression of miR-24-3p was related to poor survival of cancer patients. Consistently, ectopic expression of  ...[more]

Similar Datasets

Unknown Knockdown of lncRNA NEAT1 expression inhibits cell migration, invasion and EMT by regulating the miR-24-3p/LRG1 axis in retinoblastoma cells.
| S-EPMC7903428 | biostudies-literature
Unknown LncRNA BLACAT1 Promotes Proliferation, Migration and Invasion of Prostate Cancer Cells via Regulating miR-29a-3p/DVL3 Axis.
| S-EPMC7923982 | biostudies-literature
Unknown ADAR2/miR-589-3p axis controls glioblastoma cell migration/invasion.
| S-EPMC5829642 | biostudies-literature
Unknown Curcumin inhibits the viability, migration and invasion of papillary thyroid cancer cells by regulating the miR-301a-3p/STAT3 axis.
| S-EPMC8237388 | biostudies-literature
Unknown MiR-223-3p attenuates the migration and invasion of NSCLC cells by regulating NLRP3.
| S-EPMC9583869 | biostudies-literature
Unknown Circ_0032821 Facilitates Gastric Cancer Cell Proliferation, Migration, Invasion and Glycolysis by Regulating MiR-1236-3p/HMGB1 Axis.
| S-EPMC7567569 | biostudies-literature
Unknown ELFN1-AS1 accelerates cell proliferation, invasion and migration via regulating miR-497-3p/CLDN4 axis in ovarian cancer.
| S-EPMC8291874 | biostudies-literature
Unknown lncRNA TUG1 Promotes Cell Proliferation, Migration, and Invasion in Hepatocellular Carcinoma via Regulating miR-29c-3p/COL1A1 Axis.
| S-EPMC7425090 | biostudies-literature
Unknown Circ_0008039 supports breast cancer cell proliferation, migration, invasion, and glycolysis by regulating the miR-140-3p/SKA2 axis.
| S-EPMC7858101 | biostudies-literature
Unknown Long-Noncoding RNA FGD5-AS1 Enhances the Viability, Migration, and Invasion of Glioblastoma Cells by Regulating the miR-103a-3p/TPD52 Axis.
| S-EPMC7425657 | biostudies-literature