Septin 9_i2 is downregulated in tumors, impairs cancer cell migration and alters subnuclear actin filaments.

ABSTRACT: Functions of septin cytoskeletal polymers in tumorigenesis are still poorly defined. Their role in the regulation of cytokinesis and cell migration were proposed to contribute to cancer associated aneuploidy and metastasis. Overexpression of Septin 9 (Sept9) promotes migration of cancer cell lines. SEPT9 mRNA and protein expression is increased in breast tumors compared to normal and peritumoral tissues and amplification of SEPT9 gene was positively correlated with breast tumor progression. However, the existence of multiple isoforms of Sept9 is a confounding factor in the analysis of Sept9 functions. In the present study, we analyze the protein expression of Sept9_i2, an uncharacterized isoform, in breast cancer cell lines and tumors and describe its specific impact on cancer cell migrati

SUBMITTER: Verdier-Pinard P 

PROVIDER: S-EPMC5364497 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature