Human Immunodeficiency Virus Type-1 Myeloid Derived Suppressor Cells Inhibit Cytomegalovirus Inflammation through Interleukin-27 and B7-H4.

ABSTRACT: HIV/CMV co-infected persons despite prolonged viral suppression often experience persistent immune activation, have an increased frequency of myeloid derived suppressor cells (MDSC) and are at increased risk for cardiovascular disease. We examined how HIV MDSC control CD4⁺ T cell IFNγ response to a CMVpp65 peptide pool (CMVpp65). We show that HIV/CMV co-infected persons with virologic suppression and recovered CD4⁺ T cells compared to HIV(-)/CMV(+) controls exhibit an increase in CD4⁺CX3CR1⁺IFNγ⁺ cells in response to CMVpp65; MDSC depletion further augmented CD4⁺CX3CR1⁺IFNγ⁺ cells and IFNγ production. IL-2 and IFNγ in response to CMVpp65 were enhanced with depletion of MDSC expanded in presence of HIV (

SUBMITTER: Garg A 

PROVIDER: S-EPMC5364511 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature