Heteroleptic Copper(I) Complexes of "Scorpionate" Bis-pyrazolyl Carboxylate Ligand with Auxiliary Phosphine as Potential Anticancer Agents: An Insight into Cytotoxic Mode.

ABSTRACT: New copper(I) complexes [CuCl(PPh₃)(L)] (1: L = L_A = 4-carboxyphenyl)bis(3,5-dimethylpyrazolyl)methane; (2: L = L_B = 3-carboxyphenyl)bis(3,5-dimethylpyrazolyl)methane) were prepared and characterised by elemental analysis and various spectroscopic techniques such as FT-IR, NMR, UV-Vis, and ESI-MS. The molecular structures of complexes 1 and 2 were analyzed by theoretical B3LYP/DFT method. Furthermore, in vitro DNA binding studies were carried out to check the ability of complexes 1 and 2 to interact with native calf thymus DNA (CT-DNA) using absorption titration, fluorescence quenching and circular dichroism, which is indicative of more avid binding of the complex 1. Moreover, DNA mobility assay was also conducted to study the concentration-dependent cleava

SUBMITTER: Khan RA 

PROVIDER: S-EPMC5364558 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature