Flightless-I governs cell fate by recruiting the SUMO isopeptidase SENP3 to distinct HOX genes.

ABSTRACT:

Background

Despite recent studies on the role of ubiquitin-related SUMO modifier in cell fate decisions, our understanding on precise molecular mechanisms of these processes is limited. Previously, we established that the SUMO isopeptidase SENP3 regulates chromatin assembly of the MLL1/2 histone methyltransferase complex at distinct HOX genes, including the osteogenic master regulator DLX3. A comprehensive mechanism that regulates SENP3 transcriptional function was not understood.

Results

Here, we identified flightless-I homolog (FLII), a member of the gelsolin family of actin-remodeling proteins, as a novel regulator of SENP3. We demonstrate that FLII is associated with SENP3 and the MLL1/2 complex. We further show that FLII determines SENP3 recruitment and ML

SUBMITTER: Nayak A 

PROVIDER: S-EPMC5364561 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature