Lung function associated gene Integrator Complex subunit 12 regulates protein synthesis pathways.

ABSTRACT:

Background

Genetic studies of human lung function and Chronic Obstructive Pulmonary Disease have identified a highly significant and reproducible signal on 4q24. It remains unclear which of the two candidate genes within this locus may regulate lung function: GSTCD, a gene with unknown function, and/or INTS12, a member of the Integrator Complex which is currently thought to mediate 3'end processing of small nuclear RNAs.

Results

We found that, in lung tissue, 4q24 polymorphisms associated with lung function correlate with INTS12 but not neighbouring GSTCD expression. In contrast to the previous reports in other species, we only observed a minor alteration of snRNA processing following INTS12 depletion. RNAseq analysis of knockdown cells instead revealed dysregulation of a co

SUBMITTER: Kheirallah AK 

PROVIDER: S-EPMC5364626 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature