Genomic regions underlying susceptibility to bovine tuberculosis in Holstein-Friesian cattle.

ABSTRACT:

Background

The significant social and economic loss as a result of bovine tuberculosis (bTB) presents a continuous challenge to cattle industries in the UK and worldwide. However, host genetic variation in cattle susceptibility to bTB provides an opportunity to select for resistant animals and further understand the genetic mechanisms underlying disease dynamics.

Methods

The present study identified genomic regions associated with susceptibility to bTB using genome-wide association (GWA), regional heritability mapping (RHM) and chromosome association approaches. Phenotypes comprised de-regressed estimated breeding values of 804 Holstein-Friesian sires and pertained to three bTB indicator traits: i) positive reactors to the skin test with positive post-mortem examination resu

SUBMITTER: Raphaka K 

PROVIDER: S-EPMC5364629 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature