Effects of short-term hyperoxia on erythropoietin levels and microcirculation in critically Ill patients: a prospective observational pilot study.

ABSTRACT:

Background

The normobaric oxygen paradox states that a short exposure to normobaric hyperoxia followed by rapid return to normoxia creates a condition of 'relative hypoxia' which stimulates erythropoietin (EPO) production. Alterations in glutathione and reactive oxygen species (ROS) may be involved in this process. We tested the effects of short-term hyperoxia on EPO levels and the microcirculation in critically ill patients.

Methods

In this prospective, observational study, 20 hemodynamically stable, mechanically ventilated patients with inspired oxygen concentration (FiO₂) ≤0.5 and PaO₂/FiO₂ ≥ 200 mmHg underwent a 2-hour exposure to hyperoxia (FiO₂ 1.0). A further 20 patients acted as controls. Serum EPO was measured at baseline,

SUBMITTER: Donati A 

PROVIDER: S-EPMC5364633 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature