Radiation dose escalation based on FDG-PET driven dose painting by numbers in oropharyngeal squamous cell carcinoma: a dosimetric comparison between TomoTherapy-HA and RapidArc.

ABSTRACT:

Purpose

Validation of dose escalation through FDG-PET dose painting (DP) for oropharyngeal squamous cell carcinoma (SCC) requires randomized clinical trials with large sample size, potentially involving different treatment planning and delivery systems. As a first step of a joint clinical study of DP, a planning comparison was performed between Tomotherapy HiArt® (HT) and Varian RapidArc® (RA).

Methods

The planning study was conducted on five patients with oropharyngeal SCC. Elective and therapeutic CTVs were delineated based on anatomic information, and the respective PTVs (CTVs + 4 mm) were prescribed a dose of 56 (PTV₅₆) and 70 Gy (PTV₇₀). A gradient-based method was used to delineate automatically the external contours of the FDG-PET volume (GTV

SUBMITTER: Differding S 

PROVIDER: S-EPMC5364636 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature