OLFM4, KNG1 and Sec24C identified by proteomics and immunohistochemistry as potential markers of early colorectal cancer stages.

ABSTRACT:

Background

Despite recent advances in colorectal cancer (CRC) diagnosis and population screening programs, the identification of patients with preneoplastic lesions or with early CRC stages remains challenging and is important for reducing CRC incidence and increasing patient's survival.

Methods

We analysed 76 colorectal tissue samples originated from early CRC stages, normal or inflamed mucosa by label-free proteomics. The characterisation of three selected biomarker candidates was performed by immunohistochemistry on an independent set of precancerous and cancerous lesions harbouring increasing CRC stages.

Results

Out of 5258 proteins identified, we obtained 561 proteins with a significant differential distribution among groups of patients and controls

SUBMITTER: Quesada-Calvo F 

PROVIDER: S-EPMC5364649 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature