SVR Rates of HCV-infected population under PEG-IFN-α/R treatment in Northwest China.

ABSTRACT:

Background

Chronic HCV Patients taking PEG-IFN-α/R from different ethnic groups have different probabilities of reaching a sustained viral response (SVR). There are many influence factors, such as HCV genotype, IL-28B single-nucleotide polymorphisms (SNP), Fibrosis 4 index (FIB-4), and aspartate aminotransferase-to-platelet ratio index (APRI) score. But the baseline factors in relation to treatment outcome was still not much clear.

Methods

We evaluated data from 231 chronic HCV patients with or without liver fibrosis and their antiviral efficacy after treatment with pegylated interferon plus ribavirin (PEG-IFN-α/R) for 24-48 weeks. IL-28B SNP and HCV genotypes were analyzed with genome sequencing using pyrosequencing.

Results

Sustained viral response (SVR) rates of pa

SUBMITTER: Li Y 

PROVIDER: S-EPMC5364675 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature