Ipsilateral and contralateral sensory changes in healthy subjects after experimentally induced concomitant sensitization and hypoesthesia.

ABSTRACT:

Background

In unilateral neuropathic pain. e.g. after peripheral nerve injury, both positive and negative sensory signs occur often, accompanied by minor but equally directed contralateral sensory changes. To mimic this feature, we experimentally aimed to induce concomitant c-fibre sensitization and block in healthy subjects and analyzed the bilateral sensory changes by quantitative sensory testing (QST) using the protocol of the German Research Network on Neuropathic Pain.

Methods

Twenty eight healthy subjects were firstly randomized in 2 groups to receive either topical capsaicin (0.6%, 12 cm², application duration: 15 min.) or a lidocaine/prilocaine patch (25/25 mg, 10 cm², application duration: 60 min.) on the right volar forearm. Secondly, 7-14 day

SUBMITTER: Enax-Krumova EK 

PROVIDER: S-EPMC5364678 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature