Gene expression profiles reveal key pathways and genes associated with neuropathic pain in patients with spinal cord injury.

ABSTRACT: Previous gene expression profiling studies of neuropathic pain (NP) following spinal cord injury (SCI) have predominantly been performed in animal models. The present study aimed to investigate gene alterations in patients with spinal cord injury and to further examine the mechanisms underlying NP following SCI. The GSE69901 gene expression profile was downloaded from the public Gene Expression Omnibus database. Samples of peripheral blood mononuclear cells (PBMCs) derived from 12 patients with intractable NP and 13 control patients without pain were analyzed to identify the differentially expressed genes (DEGs), followed by functional enrichment analysis and protein‑protein interaction (PPI) network construction. In addition, a transcriptional regulation network was constructed and functi

SUBMITTER: He X 

PROVIDER: S-EPMC5364823 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature