Impaired Epidermal to Dendritic T Cell Signaling Slows Wound Repair in Aged Skin.

ABSTRACT: Aged skin heals wounds poorly, increasing susceptibility to infections. Restoring homeostasis after wounding requires the coordinated actions of epidermal and immune cells. Here we find that both intrinsic defects and communication with immune cells are impaired in aged keratinocytes, diminishing their efficiency in restoring the skin barrier after wounding. At the wound-edge, aged keratinocytes display reduced proliferation and migration. They also exhibit a dampened ability to transcriptionally activate epithelial-immune crosstalk regulators, including a failure to properly activate/maintain dendritic epithelial T cells (DETCs), which promote re-epithelialization following injury. Probing mechanism, we find that aged keratinocytes near the wound edge don't efficiently upregulate Skints o

SUBMITTER: Keyes BE 

PROVIDER: S-EPMC5364946 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature