Combatting AMR: photoactivatable ruthenium(ii)-isoniazid complex exhibits rapid selective antimycobacterial activity.

ABSTRACT: The novel photoactive ruthenium(ii) complex cis-[Ru(bpy)₂(INH)₂][PF₆]₂ (1·2PF₆, INH = isoniazid) was designed to incorporate the anti-tuberculosis drug, isoniazid, that could be released from the Ru(ii) cage by photoactivation with visible light. In aqueous solution, 1 rapidly released two equivalents of isoniazid and formed the photoproduct cis-[Ru(bpy)₂(H₂O)₂]²⁺ upon irradiation with 465 nm blue light. We screened for activity against bacteria containing the three major classes of cell envelope: Gram-positive Bacillus subtilis, Gram-negative Escherichia coli, and Mycobacterium smegmatis in vitro using blue and multi-colored LED multi-well arr

SUBMITTER: Smith NA 

PROVIDER: S-EPMC5365061 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature