Detecting congenital malformations - Lessons learned from the Mpepu study, Botswana.

ABSTRACT:

Introduction

A large and increasing number of HIV-infected women are conceiving on antiretroviral treatment (ART). While most antiretrovirals are considered safe in pregnancy, monitoring for rare pregnancy and infant adverse outcomes is warranted.

Methods

We conducted a retrospective secondary analysis nested within a clinical trial of infant cotrimoxazole vs. placebo prophylaxis in Botswana (the Mpepu Study). Infants were examined at birth, and at least every 3 months through 18 months of age. Abnormal physical findings and diagnostic testing revealing malformations were documented. Post hoc, a geneticist classified all reported malformations based on available documentation. Structural malformations with surgical, medical or cosmetic importance were classified as major mal

SUBMITTER: Ajibola G 

PROVIDER: S-EPMC5365099 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature