Dataset Information

Ulapualides C-E Isolated from a Hawaiian Hexabranchus sanguineus Egg Mass.

ABSTRACT: Three new ulapualides (3-5) were isolated from egg masses of the nudibranch Hexabranchus sanguineus. The structures of 3-5 were deduced by analyses of physical and spectroscopic data in comparisons with ulapualides A (1) and B (2). Ulapualide C demonstrated submicromolar cytotoxicity against select NCI cell lines (768-0, DU-145, MDA-MB-231, and A549) with the most potent activity against MDA-MB-231 cells (IC50 0.58 ?M). Ulapualides A (1) and B (2) were 2- to 4-fold more potent than 3.

SUBMITTER: Parrish SM

PROVIDER: S-EPMC5365346 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature

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Ulapualides C-E Isolated from a Hawaiian Hexabranchus sanguineus Egg Mass.

Parrish Stephen M SM Yoshida Wesley W Yang Baojun B Williams Philip G PG

Journal of natural products 20170118 3

Three new ulapualides (3-5) were isolated from egg masses of the nudibranch Hexabranchus sanguineus. The structures of 3-5 were deduced by analyses of physical and spectroscopic data in comparisons with ulapualides A (1) and B (2). Ulapualide C demonstrated submicromolar cytotoxicity against select NCI cell lines (768-0, DU-145, MDA-MB-231, and A549) with the most potent activity against MDA-MB-231 cells (IC<sub>50</sub> 0.58 μM). Ulapualides A (1) and B (2) were 2- to 4-fold more potent than 3. ...[more]

PMID: 28098996

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Project description:BackgroundOviparous females have three main options to increase their reproductive success: investing into egg number, egg mass and/or egg care. Although allocating resources to either of these three components is known to shape offspring number and size, potential trade-offs among them may have key impacts on maternal and offspring fitness. Here, we tested the occurrence of phenotypic trade-offs between egg number, egg mass and maternal expenditure on egg care in the European earwig, Forficula auricularia, an insect with pre- and post-hatching forms of maternal care. In particular, we used a series of laboratory observations and experiments to investigate whether these three components non-additively influenced offspring weight and number at hatching, and whether they were associated with potential costs to females in terms of future reproduction.ResultsWe found negative associations between egg number and mass as well as between egg number and maternal expenditure on egg care. However, these trade-offs could only be detected after statistically correcting for female weight at egg laying. Hatchling number was not determined by single or additive effects among the three life-history traits, but instead by pairwise interactions among them. In particular, offspring number was positively associated with the number of eggs only in clutches receiving high maternal care or consisting of heavy eggs, and negatively associated with mean egg mass in clutches receiving low care. In contrast, offspring weight was positively associated with egg mass only. Finally, maternal expenditure on egg care reduced their future reproduction, but this effect was only detected when mothers were experimentally isolated from their offspring at egg hatching.ConclusionsOverall, our study reveals simultaneous trade-offs between the number, mass and care of eggs. It also demonstrates that these factors interact in their impact on offspring production, and that maternal expenditure on egg care possibly shapes female future reproduction. These findings emphasize that studying reproductive success requires consideration of phenotypic trade-offs between egg-number, egg mass and egg care in oviparous species.

Dataset Information

Ulapualides C-E Isolated from a Hawaiian Hexabranchus sanguineus Egg Mass.

Publications

Ulapualides C-E Isolated from a Hawaiian Hexabranchus sanguineus Egg Mass.

Similar Datasets

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