Genomic Characterization of Two KPC-Producing Klebsiella Isolates Collected in 1997 in New York City.

ABSTRACT: Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae have now become a global public health threat. However, the origin of this pandemic and the characterization of pre-2003 blaKPC-harboring plasmids remain unknown. Here we used next-generation sequencing to characterize two KPC-2-producing K. pneumoniae and Kmichiganensis isolates collected from a New York City hospital in 1997. Although identified in two different Klebsiella species, the blaKPC-2 gene was harbored by Tn4401b transposons on two highly similar IncN plasmids.

SUBMITTER: Eilertson B 

PROVIDER: S-EPMC5365676 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature