Troponoids Can Inhibit Growth of the Human Fungal Pathogen Cryptococcus neoformans.

ABSTRACT: Cryptococcus neoformans is a pathogen that is common in immunosuppressed patients. It can be treated with amphotericin B and fluconazole, but the mortality rate remains 15 to 30%. Thus, novel and more effective anticryptococcal therapies are needed. The troponoids are based on natural products isolated from western red cedar, and have a broad range of antimicrobial activities. Extracts of western red cedar inhibit the growth of several fungal species, but neither western red cedar extracts nor troponoid derivatives have been tested against C. neoformans We screened 56 troponoids for their ability to inhibit C. neoformans growth and to assess whether they may be attractive candidates for development into anticryptococcal drugs. We determined MICs at which the compounds

SUBMITTER: Donlin MJ 

PROVIDER: S-EPMC5365692 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature