DRP1 Suppresses Leptin and Glucose Sensing of POMC Neurons.

ABSTRACT: Hypothalamic pro-opiomelanocortin (POMC) neurons regulate energy and glucose metabolism. Intracellular mechanisms that enable these neurons to respond to changes in metabolic environment are ill defined. Here we show reduced expression of activated dynamin-related protein (pDRP1), a mitochondrial fission regulator, in POMC neurons of fed mice. These POMC neurons displayed increased mitochondrial size and aspect ratio compared to POMC neurons of fasted animals. Inducible deletion of DRP1 of mature POMC neurons (Drp1^fl/fl-POMC-cre:ER^T2) resulted in improved leptin sensitivity and glucose responsiveness. In Drp1^fl/fl-POMC-cre:ER^T2 mice, POMC neurons showed increased mitochondrial size, ROS production, and neuronal activation with increased expressio

SUBMITTER: Santoro A 

PROVIDER: S-EPMC5366041 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature