Quantification and biodistribution of iron oxide nanoparticles in the primary clearance organs of mice using T₁ contrast for heating.

ABSTRACT:

Purpose

To use contrast based on longitudinal relaxation times (T₁ ) or rates (R₁ ) to quantify the biodistribution of iron oxide nanoparticles (IONPs), which are of interest for hyperthermia therapy, cell targeting, and drug delivery, within primary clearance organs.

Methods

Mesoporous silica-coated IONPs (msIONPs) were intravenously injected into 15 naïve mice. Imaging and mapping of the longitudinal relaxation rate constant at 24 h or 1 week postinjection were performed with an echoless pulse sequence (SWIFT). Alternating magnetic field heating measurements were also performed on ex vivo tissues.

Results

Signal enhancement from positive T₁ contrast caused by IONPs was observed and quantified in vivo in liver, spleen, and kidney at c

SUBMITTER: Zhang J 

PROVIDER: S-EPMC5366089 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature