Neural correlates of rumination in adolescents with remitted major depressive disorder and healthy controls.

ABSTRACT: The aim of the present study was to use fMRI to examine the neural correlates of engaging in rumination among a sample of remitted depressed adolescents, a population at high risk for future depressive relapse. A rumination induction task was used to assess differences in the patterns of neural activation during rumination versus a distraction condition among 26 adolescents in remission from major depressive disorder (rMDD) and in 15 healthy control adolescents. Self-report depression and rumination, as well as clinician-rated depression, were also assessed among all participants. All of the participants recruited regions in the default mode network (DMN), including the posterior cingulate cortex, medial prefrontal cortex, inferior parietal lobe, and medial temporal gyrus, during ruminatio

SUBMITTER: Burkhouse KL 

PROVIDER: S-EPMC5366093 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature