Inflammatory signature of cerebellar neurodegeneration during neonatal hyperbilirubinemia in Ugt1 ^-/- mouse model.

ABSTRACT:

Background

Severe hyperbilirubinemia is toxic during central nervous system development. Prolonged and uncontrolled high levels of unconjugated bilirubin lead to bilirubin-induced neurological damage and eventually death by kernicterus. Bilirubin neurotoxicity is characterized by a wide array of neurological deficits, including irreversible abnormalities in motor, sensitive and cognitive functions, due to bilirubin accumulation in the brain. Despite the abundant literature documenting the in vitro and in vivo toxic effects of bilirubin, it is unclear which molecular and cellular events actually characterize bilirubin-induced neurodegeneration in vivo.

Methods

We used a mouse model of neonatal hyperbilirubinemia to temporally and spatially define the response of the developin

SUBMITTER: Vodret S 

PROVIDER: S-EPMC5366125 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature