Protein Corona-Induced Modification of Silver Nanoparticle Aggregation in Simulated Gastric Fluid.

ABSTRACT: Due to their widespread incorporation into a range of biomedical and consumer products, the ingestion of silver nanoparticles (AgNPs) is of considerable concern to human health. However, the extent to which AgNPs will be modified within the gastric compartment of the gastrointestinal tract is still poorly understood. Studies have yet to fully evaluate the extent of physicochemical changes to AgNPs in the presence of biological macromolecules, such as pepsin, the most abundant protein in the stomach, or the influence of AgNPs on protein structure and activity. Herein, AgNPs of two different sizes and surface coatings (20 and 110 nm, citrate or polyvinylpyrrolidone) were added to simulated gastric fluid (SGF) with or without porcine pepsin at three pHs (2.0, 3.5, and 5.0), representing a ran

SUBMITTER: Ault AP 

PROVIDER: S-EPMC5366255 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature