The Evolution and Expression Pattern of Human Overlapping lncRNA and Protein-coding Gene Pairs.

ABSTRACT: Long non-coding RNA overlapping with protein-coding gene (lncRNA-coding pair) is a special type of overlapping genes. Protein-coding overlapping genes have been well studied and increasing attention has been paid to lncRNAs. By studying lncRNA-coding pairs in human genome, we showed that lncRNA-coding pairs were more likely to be generated by overprinting and retaining genes in lncRNA-coding pairs were given higher priority than non-overlapping genes. Besides, the preference of overlapping configurations preserved during evolution was based on the origin of lncRNA-coding pairs. Further investigations showed that lncRNAs promoting the splicing of their embedded protein-coding partners was a unilateral interaction, but the existence of overlapping partners improving the gene expression was b

SUBMITTER: Ning Q 

PROVIDER: S-EPMC5366806 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature