Differential roles of caspase-1 and caspase-11 in infection and inflammation.

ABSTRACT: Caspase-1, also known as interleukin-1β (IL-1β)-converting enzyme (ICE), regulates antimicrobial host defense, tissue repair, tumorigenesis, metabolism and membrane biogenesis. On activation within an inflammasome complex, caspase-1 induces pyroptosis and converts pro-IL-1β and pro-IL-18 into their biologically active forms. "ICE^-/-" or "Casp1^-/-" mice generated using 129 embryonic stem cells carry a 129-associated inactivating passenger mutation on the caspase-11 locus, essentially making them deficient in both caspase-1 and caspase-11. The overlapping and unique functions of caspase-1 and caspase-11 are difficult to unravel without additional genetic tools. Here, we generated caspase-1-deficient mouse (Casp1^Null) on the C57BL/6 J background that expressed

SUBMITTER: Man SM 

PROVIDER: S-EPMC5366862 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature