Tissue resident memory T cells in the human conjunctiva and immune signatures in human dry eye disease.

ABSTRACT: Non-recirculating resident memory (T_RM) and recirculating T cells mount vigorous immune responses to both self and foreign antigens in barrier tissues like the skin, lung and gastrointestinal tract. Using impression cytology followed by flow cytometry we identified two T_RM subsets and four recirculating T-subsets in the healthy human ocular surface. In dry eye disease, principal component analysis (PCA) revealed two clusters of patients with distinct T-cell signatures. Increased conjunctival central memory and naïve T cells characterized Cluster-1 patients, and increased CD8⁺ T_RMs and CD4⁺ recirculating memory T cells characterized Cluster-2 patients. Interestingly these T-cell signatures are associated with different clinical features

SUBMITTER: Bose T 

PROVIDER: S-EPMC5366884 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature